Impact of diet and exercise in growth restricted female rats on nephron endowment in male fetuses

Abstract

Uteroplacental insufficiency impairs kidney development and programs male-onset cardiorenal disease, which can be transmitted to subsequent generations. Maternal lifestyle factors can independently influence fetal kidney development, highlighting that the lifestyle of growth-restricted females can have further influence on F2 kidney development. In this study, we examined the impact of maternal growth restriction with or without additional lifestyle factors on F2 male kidney development. Uteroplacental insufficiency (Restricted) or sham (Control) surgery was performed on embryonic day 18 in Wistar–Kyoto rats. F1 females were fed a Chow or High-fat diet from weaning (5 weeks of age). At 16 we..